بكالوريوس / Bachelor's

Objectives This study aims to assess the effect of malaria infection on lipid profile parameters, specifically total cholesterol and triglyceride levels, among patients in Eldabba City, Northern Sudan. It also seeks to determine the relationship between malaria parasite species, parasite density, and lipid profile alterations, and to provide baseline data for future research. Methodology A case–control pilot study will be conducted in 2025–2026, including 100 participants (50 malaria-positive patients and 50 age- and sex-matched healthy controls). Malaria diagnosis will be confirmed by microscopy or rapid diagnostic tests. Fasting serum samples will be analyzed for total cholesterol and triglycerides. Statistical analysis will include descriptive statistics, comparison tests, and correlation analysis, with significance set at p < 0.05. Expected Outcomes Malaria patients are expected to have lower total cholesterol and higher triglyceride levels compared to controls. These changes may correlate with parasite density, supporting the potential role of lipid profiles as biomarkers of malaria severity.

Participants’ confidentiality will be ensured by using unique identification codes instead of names. All data will be stored securely and accessed only by the research team. Results will be reported in aggregate form, and informed consent will be obtained from all participants.

The potential risks are minimal and include mild pain or bruising at the blood sampling site and a rare possibility of temporary dizziness, as well as minor psychological discomfort related to testing or results. There are no significant social or economic risks, and full confidentiality and participant safety will be maintained.

The potential benefits of this study include providing participants with free laboratory testing for total cholesterol and triglyceride levels, enabling early detection of lipid abnormalities and appropriate medical follow-up, as well as increasing health awareness about the metabolic effects of malaria. At the community level, the study will generate valuable local data from Eldabba City on malaria-related lipid changes, which may support improved clinical practice, inform public health policies and malaria control programs, and serve as baseline evidence for future research aimed at improving public health outcomes and reducing the burden of malaria.